{"id":8394,"date":"2021-12-15T16:54:43","date_gmt":"2021-12-15T16:54:43","guid":{"rendered":"https:\/\/translationalneurosciencecenter.org\/staging\/9870\/?page_id=8394"},"modified":"2026-04-07T16:40:37","modified_gmt":"2026-04-07T16:40:37","slug":"accomplishments","status":"publish","type":"page","link":"https:\/\/translationalneurosciencecenter.org\/staging\/9870\/accomplishments\/","title":{"rendered":"Accomplishments"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Home 2 Content Pg” _builder_version=”4.16″ _module_preset=”default” background_color=”#bbe4ed” background_image=”https:\/\/translationalneurosciencecenter.org\/staging\/9870\/wp-content\/uploads\/2022\/02\/rsz-tnc-header-about-1000×200-1.jpg” background_size=”initial” background_position=”top_center” width_phone=”auto” width_last_edited=”off|desktop” max_width_last_edited=”off|desktop” module_alignment=”center” min_height_tablet=”300px” min_height_last_edited=”off|desktop” height=”200px” height_tablet=”154px” height_phone=”100px” height_last_edited=”on|phone” max_height_tablet=”300px” max_height_phone=”300px” max_height_last_edited=”off|desktop” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” top_divider_height_tablet=”” top_divider_height_phone=”50px” top_divider_height_last_edited=”on|phone” bottom_divider_style=”curve” bottom_divider_color=”#FFFFFF” bottom_divider_height=”70px” bottom_divider_arrangement=”above_content” bottom_divider_height_tablet=”70px” bottom_divider_height_phone=”50px” bottom_divider_height_last_edited=”on|desktop” background_last_edited=”on|phone” background_image_phone=”https:\/\/translationalneurosciencecenter.org\/staging\/9870\/wp-content\/uploads\/2022\/02\/rsz-tnc-mobile-stars.jpg” background_enable_image_phone=”on” parallax_tablet=”off” parallax_phone=”off” background_size_tablet=”contain” background_size_phone=”initial” background_position_tablet=”top_center” background_position_phone=”top_right” module_alignment_tablet=”right” module_alignment_phone=”left” module_alignment_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.16″ _module_preset=”default” module_alignment=”center” custom_margin=”0px||||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” z_index=”10″ custom_margin=”30px||||false|false” global_colors_info=”{}”]<\/p>\n

About Us<\/h1>\n

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Accomplishments<\/h2>\n

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TNC 2025 Highlights<\/h2>\n

In the past year, the Zander Wyss TNC maintained its global leadership in neurodevelopmental clinical research. We expanded clinical trials, published discoveries in high-impact journals, and launched major international collaborations to advance therapies for rare disorders.<\/p>\n

Here is a summary of this year\u2019s accomplishments.
Download the PDF of our full Annual Report.<\/a><\/p>\n

Scope of Research<\/strong>
Over 30 rare and ultra-rare neurodevelopmental disorders under investigation.<\/p>\n

Clinical Trials<\/strong>
80 active clinical trials ><\/a><\/p>\n

Publications<\/strong>
170 peer-reviewed articles since 2021. Contributions in 2025 advanced gene editing, neurogenetics, and translational neuroscience in leading journals.
Publications ><\/a><\/p>\n

IMPACT Network<\/strong>
In 2025, Boston Children\u2019s Hospital received a $7.5 million award to help lead the Aligning Research in Autism IMPACT Network, a global clinical trials infrastructure accelerating precision therapies for neurodevelopmental disorders. We serve as co-leader of the Clinical Coordinating Core.
Read more about the IMPACT Network ><\/a><\/p>\n

Clinical Research Unit<\/strong>
The Clinical Research Unit at Two Brookline Place, established in 2024, is now fully operational. This unit supports a growing portfolio of studies, providing integrated services for pharmaceutical, device, and behavioral trials. To date, 28 principal investigators have conducted study visits in our purpose-built, patient-centered space.
Read more about the Clinical Research Unit ><\/a><\/p>\n

TNC Faculty<\/strong>
With the 2025 hiring of Dr Audrey Thurm, our full-time dedicated faculty is up to six principal investigators.
Visit our Faculty page ><\/a><\/p>\n

Grants Giving<\/strong>
Our investment in early-stage innovation continues to drive impact, with pilot-funded investigators securing major follow-on funding and national recognition, while fellows advance into independent research careers.
Read more about TNC Pilot Grants ><\/a><\/p>\n

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2025 Annual Report<\/h3>\n

[\/et_pb_text][et_pb_image src=”https:\/\/translationalneurosciencecenter.org\/staging\/9870\/wp-content\/uploads\/2026\/04\/TNC-AnnualReport-2025.webp” alt=”TNC Annual Report 2025″ title_text=”TNC-AnnualReport-2025.webp” url=”https:\/\/translationalneurosciencecenter.org\/staging\/9870\/wp-content\/uploads\/2026\/04\/TNC-Annual-Report-2025.pdf” url_new_window=”on” align=”center” _builder_version=”4.27.6″ _module_preset=”_initial” background_color=”#ededed” height=”380px” custom_margin=”||-1px|||” custom_padding=”11px|||||” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” background_color=”#ededed” custom_margin=”0px||0px||false|false” custom_padding=”10px|16px|0px|16px|false|true” border_style_all=”none” border_color_bottom=”#000000″ border_style_bottom=”none” locked=”off” global_colors_info=”{}” link_text_color__hover_enabled=”on|hover” link_text_color__hover=”#0C71C3″]<\/p>\n

Download the PDF ><\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#ededed” custom_margin=”50px||||false|false” custom_padding=”24px|0px|29px|0|false|false” global_colors_info=”{}”][et_pb_row column_structure=”2_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|40px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||1px|||” global_colors_info=”{}”]<\/p>\n

TNC 2024 Highlights<\/h2>\n

In our fourth year we accomplished a significant expansion in the scope and output of our research community, new research awards, and the inauguration and operation of our Clinical Research Unit.<\/p>\n

Clinical Trials<\/strong>
We are actively investigating 23 rare and ultra-rare brain disorders, with 66 clinical trials underway, and 24 additional trials prepared to launch.
Active Clinical Research Studies ><\/a><\/p>\n

Publications<\/strong>
Publishing multiple basic, clinical and translational research projects focused on neurodevelopmental disorders in 2024
Publications ><\/a><\/p>\n

Events<\/strong>
On September 23, 2024, we hosted over 200 scientists, clinicians, patient advocates, and families in Boston for our fifth full-day symposium entitled \u201cPaving the Path: Clinical Trial Readiness and Developing Therapies for Rare Genetic Disorders\u201d.
TNC 2024 Symposium ><\/a><\/p>\n

Pilot Grants\u2028Awards of $100,000 each have been made to three new projects.
TNC Pilot Grants ><\/a><\/p>\n

TNC Clinical Research Unit<\/strong>
2024 saw the opening at our Two Brookline Place headquarters of state-of-the-art facilities for observational studies and therapeutic clinical trials specific for neurodevelopmental disorders. The new space is dedicated to research on rare and ultra-rare neurogenetic disorders, paving the way for later-stage external investment in new therapeutics.
Clinical Research Unit ><\/a><\/p>\n

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Download the PDF ><\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#ededed” custom_margin=”50px||||false|false” custom_padding=”24px|0px|29px|0|false|false” global_colors_info=”{}”][et_pb_row column_structure=”2_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|40px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||1px|||” global_colors_info=”{}”]<\/p>\n

TNC 2023 Highlights<\/h2>\n

The 2023 report highlights key achievements in our second year of operations including:<\/p>\n

Clinical Trials<\/strong>
Launching a new gene therapy trial for girls with Rett Syndrome in partnership with Neurogene<\/a>
Opening a Clinical Research Unit<\/a> at 2 Brookline Place for clinical trial study visits<\/p>\n

Faculty Members<\/strong>
Recruiting three brilliant new faculty members: Mandana Arbab<\/a>, Jordan Farrell<\/a> and Emily Osterweil<\/a><\/p>\n

Events<\/strong>
Partnering with Global Genes and hosting a panel on the \u201cPower of Partnering\u201d at the Rare Advocacy Summit<\/a> on Collaborative Research for Neurodevelopmental Disorders<\/p>\n

Training Initiatives<\/strong>
Hosting a translational neuroscience fellowship program<\/a>
Awarding 4 TNC Pilot Grants<\/a>
Launching a new Clinical Psychology Advanced Graduate Practicum<\/a><\/p>\n

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Download the PDF ><\/a><\/p>\n

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TNC 2022 Highlights<\/h2>\n

<\/strong><\/p>\n

The 2022 report highlights key achievements in our second year of operations including:<\/p>\n

Symposium<\/strong>
Hosting an inaugural symposium entitled Gene Therapy for Pediatric Neurological Disorders and multiple community\/science meetings\u00a0 LEARN MORE ><\/a><\/p>\n

New Advisory Council<\/strong>
Launching a Neuroscience Family Advisory Council research committee to ensure our clinical research includes the patient and family perspective LEARN MORE ><\/a><\/p>\n

Faculty Members<\/strong>
Recruiting two new faculty members to lead TNC Cores: Dr. Jed Hubbs, Director of Medicinal Chemistry Core<\/a> and Dr. Maya Chopra, Director of Translational Genomic Medicine Core<\/a><\/p>\n

Pilot Grants<\/strong>
Awarding two new $100,000 TNC Pilot grants<\/a><\/p>\n

Human Neuron Core<\/strong>
Sharing of standard operating procedures and tools developed by the Human Neuron Core<\/p>\n

Publications<\/strong>
Publishing a seminal paper proposing a new framework for evaluation of disorders for development of gene therapy, GENE TARGET\u00a0 READ THE PAPER ><\/a><\/p>\n

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Download the PDF ><\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.17.6″ _module_preset=”default” background_color=”#ededed” custom_margin=”50px||||false|false” custom_padding=”24px|0px|29px|0|false|false” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.19.4″ _module_preset=”default” background_color=”#ededed” custom_padding=”0px|0px|0|0px|false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” background_color=”#ededed” custom_margin=”0px||0px||false|false” custom_padding=”10px|16px|0px|16px|false|true” global_colors_info=”{}”]<\/p>\n

TNC 2021 Highlights<\/h2>\n

<\/strong><\/p>\n

Leadership Team<\/strong>
Key appointments: Executive Director, new Core Directors, Strategic Advisory Council.<\/p>\n

Fellowship Awards<\/strong>
Two Translational Neuroscience Fellowships<\/a>: the postdoctoral training program is two years in duration.<\/p>\n

Pilot Grants<\/strong>
Four $100,000 awards to principal investigators\u00a0for one-year TNC Pilot grants<\/a>, with the possibility for a renewal the subsequent year.<\/p>\n

Scientific\/Family Conferences<\/strong>
We partner with patient advocacy groups to plan and conduct meetings between families and researchers. Learn more about\u00a0TNC Events<\/a>.<\/p>\n

New Gene Therapy Core<\/strong>
Completed national search for two new faculty. Read more about our Core Facilities<\/a>.<\/p>\n

New Clinical and Research Space<\/strong>
The TNC Research Center at 2 Brookline Place opens in July 2023.<\/p>\n

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“Driving patient-centered research and care forward: A report on the Rosamund Stone Zander Translational Neuroscience Center.”<\/em><\/p>\n

This December 2021 report summarizes the accomplishments achieved in our first year of operations.<\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/translationalneurosciencecenter.org\/staging\/9870\/wp-content\/uploads\/2022\/01\/RSZ_Booklet3.png” alt=”RSZ_Booklet” title_text=”RSZ_Booklet3″ show_bottom_space=”off” align=”center” _builder_version=”4.19.4″ _module_preset=”_initial” background_color=”#ededed” module_alignment=”center” height=”300px” custom_margin=”0px||0px||false|false” custom_padding=”5px|15px|15px|15px|false|true” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” link_text_color=”#000000″ header_2_text_color=”#0062a6″ header_3_text_color=”#0C71C3″ background_color=”RGBA(255,255,255,0)” custom_margin=”0px||0px||false|false” custom_padding=”10px||10px|0px|false|false” border_style_all=”none” border_color_bottom=”#000000″ border_style_bottom=”none” locked=”off” global_colors_info=”{}” link_text_color__hover_enabled=”on|hover” link_text_color__hover=”#0C71C3″]<\/p>\n

Download the PDF ><\/a><\/p>\n

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